FUNCTIONS OF LYMPH AND FIBROLYTIC SYSTEM
5. COMPOSITION & FUNCTIONS OF LYMPH
Composition of Lymph
Electrolytes – same as that of
plasma
Minerals – Ca₂₊ & phosphorous are
lower than plasma
Protein – lower than that of plasma
Aminoacids – same as that plasma
Urea & creatinine – same as that
of plasma
Glucose & chlorides – more than
that of plasma
Cells – Lymphocytes & plasma
cells are present
Clotting factor and
antibodies are present.
Functions of Lymph
·
Returns
protein, electrolytes and water to the blood from the tissue spaces
·
Removes
the bacteria and particulate matter
6. FIBRINOLYTIC
SYSTEM
Fibrinolysis
refers to the process of dissolution of fibrin. Fibrinolytic system
refers to the substances taking part in fibrinolysis.
The
important components of fibrinolytic system:
Protein
C, tissue plasminogen activator & plasmin or fibrinolysin which is present
in an inactive form (plasminogen)
Protein C → Activated protein C
 |
Inactivates
clotting Inactivates inhibitor of
tissue plasminogen activator
Factors
V a & VIIIa ↓
Activation
of tissue plasminogen activator
↓
Plasminogen
Plasmin
(fibrinolysis)
Fibrinolysin
lyses fibrin into soluble fragments called as fibrin degradation products which
inhibit thrombin
Plasminogen Activaor system
Intrinsic: Factor XIIa and Kallikrein
Extrinsic: Tissue plasminogen activator,
Streptokinase and staphylokinase
Physiological role of
fibrinolytic system
·
Cleans
the minute clots of tiny vessels
·
Promotes
normal healing process
·
Dissolution
of menstrual clot
·
Dissolution
of sperms in the epididymis
Therapeutic role of fibrinolytic
system
Streptokinase and staphylokinase are
bacterial enzymes that activate plasminogen to
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